克罗恩病基因
克罗恩病,是一种消化道的慢性、反复发作的炎症。平均人群每 10 万人中出现该疾病 1 例。
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相关知识
发病时间
任何年龄均可发病,但青壮年(20~29岁)居多。
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流行程度
欧美地区发病率较高,亚洲和拉丁美洲发病率较低。我国克罗恩病发病率低于欧美国家,同时也低于韩国、日本等其他亚洲国家,为0.848/10万人,大多数分布在我国的北部、东部、南部地区。
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典型症状
病程呈慢性,多数患者反复发作,迁延不愈。
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- 消化系统症状:腹痛、腹泻、腹部包块、瘘管形成和肠梗阻。
- 全身表现:发热、营养障碍,急性发作期有水、电解质、酸碱平衡紊乱。
- 肠外表现:关节、皮肤、眼、口腔黏膜等病变。
治疗方法
目前尚无根治方法,可通过药物、手术缓解病情和预防复发。 认知人类基因
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影响因素
- 可控因素
- 吸烟:吸烟是克罗恩病的危险因素,吸烟者较不吸烟者患克罗恩病的概率高2~5倍。
- 感染:许多微生物,如副结核分支杆菌、李斯特菌、沙眼衣原体、大肠埃希菌、巨细胞细菌等,可能增加患克罗恩病的风险。
- 不可控因素
家族病史:克罗恩病会出现家族聚集现象,尤其是当父母或兄弟姐妹患有此病,会增高患克罗恩病的风险。 renDNA.com
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检测的基因
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保健建议
- 吸烟是克罗恩病的重要危险因素,建议戒烟和避免二手烟。
- 细菌感染可能增加克罗恩病的风险,所以应注意禁食不洁食物,进餐前洗手。
认知人类基因
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参考文献
- A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
- Functional variants of OCTN cation transporter genes are associated with Crohn disease
- Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
- Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn disease susceptibility
- A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
- Contribution of rs11465788 in IL23R gene to Crohn’s disease susceptibility and phenotype in Chinese population
- Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
- Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease
- Susceptibility loci reported in genome-wide association studies are associated with Crohn’s disease in Canadian children
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
- Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease
- Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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